解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Aryl hydrocarbon receptor nuclear translocator (ARNT) is a transcription factor that has been reported to play a vital role in regulating glycolysis, angiogenesis and apoptosis. Recently, ARNT has been reported to a play role in pancreatic-islet function in type 2 diabetes. However, the role of ARNT in kidney cancer h...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11917
更新日期:2020-10-01 00:00:00
abstract::Immune checkpoint inhibitors (ICIs) have emerged as one of the most promising therapeutic options for patients with advanced cancer. The aim of the present study was to investigate the prognostic value of somatic mutations in mismatch repair (MMR) genes in metastatic cancers after ICI treatment, as well as their assoc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11888
更新日期:2020-10-01 00:00:00
abstract::The present study compared two methods for the detection of severe cervical dysplasia in women with atypical squamous cells of underdetermined significance (ASC-US) cytology; digital colposcopy with adjunctive dynamic spectral imaging (DSI) and conventional colposcopy. IMPROVE-COLPO was a two-arm cross-sectional study...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11878
更新日期:2020-10-01 00:00:00
abstract::Pituitary tumor transforming gene 1 (PTTG11) is abundantly expressed in glioma. Our previous study demonstrated that the downregulation of PTTG11 gene expression significantly inhibited the proliferation, migration and invasion ability, and increased the apoptosis of SHG44 glioma cells. However, the molecular mechanis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11867
更新日期:2020-10-01 00:00:00
abstract::Cutaneous melanoma (CM) is the most aggressive form of skin cancer, exhibits an increasing incidence worldwide and has a high potential to develop metastasis. The current study aimed to identify a set of parameters that may aid in predicting the probability and timing of the onset of CM metastasis. A retrospective ana...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11978
更新日期:2020-10-01 00:00:00
abstract::Breast cancer is a highly heterogeneous disease at the molecular level and >90% of mortalities are due to metastasis and its associated complications. The present study determined the impact of molecular subtypes on metastatic behavior and overall survival (OS) of patients with metastatic breast cancer. The influence ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11948
更新日期:2020-10-01 00:00:00
abstract::Breast lumpectomy is usually performed under general or local anesthesia. To the best of our knowledge, whether conscious sedation with intranasal dexmedetomidine and local anesthesia is an effective anesthetic technique has not been studied. Thus, the present study aimed to investigate the effectiveness of conscious ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11938
更新日期:2020-10-01 00:00:00
abstract::Micheliolide (MCL), a sesquiterpene lactone isolated from Michelia compressa and Michelia champaca, has been used previously to inhibit the NF-κB signaling pathway. MCL has exerted various therapeutic effects in numerous types of disease, such as inflammatory and cancer. However, to the best of our knowledge, its unde...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11928
更新日期:2020-10-01 00:00:00
abstract::Long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is upregulated in numerous types of cancer, and is implicated in various cellular processes associated with cancer progression. However, the underlying molecular mechanisms by which MALAT1 regulates metastasis remain unclear. ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11914
更新日期:2020-10-01 00:00:00
abstract::Several previous studies have shown that mutations in B-Raf proto-oncogene (BRAF) and telomerase reverse transcriptase (TERT) can be used for the diagnosis and prognosis of papillary thyroid carcinoma (PTC). However, whether mutations in BRAF and the TERT promoter may improve the accurate identification and risk strat...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11904
更新日期:2020-10-01 00:00:00
abstract::Chimeric antigen receptor (CAR) T cells have an unprecedented positive curative effect for hematological malignances. Most notably, cluster of differentiation 19 (CD19) CAR T-cell therapy for pediatric acute lymphoblastic leukemia is associated with a high complete remission rate and has aroused considerable attention...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2020.11897
更新日期:2020-10-01 00:00:00
abstract::It is crucial to classify cervical lesions into high-grade squamous intraepithelial lesions (HSILs) and low-grade SILs (LSILs), as LSILs are conservatively treated by observation, based on an expectation of natural regression, whereas HSILs usually require electrosurgical excision. In the present study, peripheral blo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11779
更新日期:2020-09-01 00:00:00
abstract::Glioma is one of the most prevalent types of malignancy in the central nervous system worldwide, and the prognosis of patients with late stage glioma remains poor. Thus, the development of promising therapeutic strategies against glioma is essential. Long non-coding RNAs (lncRNAs) are functional RNA molecules involved...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11847
更新日期:2020-09-01 00:00:00
abstract::Colorectal cancer (CRC) is a leading cause of cancer-associated mortality worldwide; therefore, there is an emerging need for novel experimental models that allow for the identification and validation of biomarkers for CRC-specific progression. In the present study, a repeated sphere-forming assay was used as a strate...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11829
更新日期:2020-09-01 00:00:00
abstract::Emerging evidence has revealed that mitochondrial DNA (mtDNA) is encapsulated in plasma extracellular vesicles (EVs). However, the characteristics of mtDNA in EVs from patients with cancer remain largely unexplored, which greatly limits its clinical application. Whole genome and capture-based sequencing found that EV ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11831
更新日期:2020-09-01 00:00:00
abstract::Diffusion weighted imaging (DWI) has been found to increase the sensitivity in the diagnosis of small hepatocellular carcinoma (HCC), although additional studies are required to confirm its value. The aim of the present study was to explore the diagnostic performance of DWI combined with contrast-enhanced magnetic res...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11805
更新日期:2020-09-01 00:00:00
abstract::Gastric cancer (GC) is one of the most common malignancies and is the second leading cause of cancer-associated mortality world-wide. In the present study, the prognostic value and antitumor effects of transforming growth factor β1 (TGFβ1) and its receptors in GC were explored. The online Kaplan-Meier plotter database...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11849
更新日期:2020-09-01 00:00:00
abstract::Manganese superoxide dismutase (MnSOD) promotes invasive and migratory activities by upregulating Forkhead box protein M1 (FoxM1) expression. The present study investigated whether modulation of MnSOD and FoxM1 expression was responsible for the antitumor effects of genistein on cancer stem-like cells (CSLCs) derived ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11802
更新日期:2020-09-01 00:00:00
abstract::The frequency of deficient mismatch repair (dMMR) or microsatellite instability-high colorectal cancer (CRC) is estimated to be ~15% of all patients with CRC; however, the patients reported are limited to surgical cases, and the frequency of patients exhibiting stage 0 disease is not considered, despite the currently ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11799
更新日期:2020-09-01 00:00:00
abstract::Preoperative radiotherapy improves local disease control and disease-free survival in patients with advanced rectal cancer; however, a reliable predictive biomarker for the effectiveness of irradiation has yet to be elucidated. Phosphorylation of H2A histone family member X (H2AX) to γ-H2AX is induced by DNA double-st...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11788
更新日期:2020-09-01 00:00:00
abstract::The aim of the present study was to explore the value of shear wave elastography (SWE) in the differential diagnosis of cervical disease and to evaluate the infiltration of cervical cancer. A total of 40 inpatients with cervical cancer, 40 inpatients with cervical benign lesion and 40 healthy volunteers encountered be...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11759
更新日期:2020-09-01 00:00:00
abstract::The present study aimed to conduct a prognosis analysis of Taiwanese patients with metastatic gastrointestinal stromal tumors (GISTs), who are resistant to or were unable to tolerate imatinib or sunitinib, and were subsequently treated with regorafenib. The study considered the survival, potential prognostic factors a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11756
更新日期:2020-09-01 00:00:00
abstract::Clinical application value was investigated of transvaginal color Doppler ultrasound (TV-CDS) combined with serum tumor markers carbohydrate antigen 125 (CA125), vascular endothelial growth factor (VEGF) and osteopontin (OPN) in the diagnosis of ovarian cancer (OC). One hundred and six patients with OC [malignant tumo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11705
更新日期:2020-08-01 00:00:00
abstract::Increasing evidence has indicated that the dysregulation of microRNA (miRNA) occur in the pathogenesis of retinoblastoma (RB). Aim of the present study was to investigate the possible role of miR-494 (miR-494-3p) in RB. It was demonstrated that miR-494 expression was increased in RB tissue samples and cell lines. Also...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11749
更新日期:2020-08-01 00:00:00
abstract::Invasive breast carcinoma (BRCA) is a serious disease that threatens the survival time of those affected. Alternative splicing (AS) involved in BRCA pathogenesis may be a potential therapeutic target. However, to the best of our knowledge, a systematic analysis of survival-related alternative splicing events (SREs) ha...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11695
更新日期:2020-08-01 00:00:00
abstract::Lung adenocarcinoma (LUAD) is a major subtype of non-small cell lung cancer. Despite significant progress in its diagnosis and treatment, the mortality and morbidity rate of LUAD remains high worldwide. The aim of the present study was to perform a systematic investigation of the tumor microenvironment (TME) and ident...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11735
更新日期:2020-08-01 00:00:00
abstract::The present study aimed to analyse the relationship between tumour-infiltrating immune cells (TIICs) and the prognosis of bladder cancer (BC). In the present study, an established computational method (CIBERSORT) was used to analyse the gene expression profile of BC from 409 patients to infer the number of infiltratin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11750
更新日期:2020-08-01 00:00:00
abstract::Preeclampsia (PE) is characterized by gestational hypertension and proteinuria, and is a leading cause of maternal death and perinatal morbidity globally. Although the exact cause of PE remains unclear, several studies have suggested a role for abnormal expression of multiple genes. The aim of the present study was to...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11721
更新日期:2020-08-01 00:00:00
abstract::This study investigated energy metabolism and its association with inflammatory cytokines and appetite- regulating hormones in patients with gastrointestinal cancer. Subjects were inpatients scheduled to undergo therapeutic intervention for diagnosed gastrointestinal cancer. Nutritional status on admission was assesse...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11662
更新日期:2020-08-01 00:00:00
abstract::While erlotinib is primarily administered to patients with non-small cell lung cancer with sensitizing epidermal growth factor receptor (EGFR) mutations, it is also prescribed to patients with wild type (wt) EGFR in higher lines of treatment. However, there is no predictive marker for erlotinib efficacy in patients wi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11663
更新日期:2020-08-01 00:00:00
abstract::Application of dexmedetomidine combined with sufentanil in colon cancer resection and its effect on immune and coagulation function of patients was studied. Colon cancer cases (n=176) admitted to Xiangya Hospital Central South University were selected into the study. They were divided into group A (n=92) and group B (...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11643
更新日期:2020-08-01 00:00:00
abstract::Laryngeal squamous cell carcinoma (LSCC) is a genetically complex tumor type and one of the leading causes of cancer-associated disability and mortality. Genetic instability, such as chromosomal instability, is associated with the tumorigenesis of LSCC. Copy number variations (CNVs) have been demonstrated to contribut...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11653
更新日期:2020-08-01 00:00:00
abstract::Although ring finger protein 2 (RNF2) serves an important role in the occurrence, development and regulation of various types of cancer, RNF2 expression in skin squamous cell carcinoma (SCC) remains unknown. The aim of the present study was to investigate the role of RNF2 expression in SCC and adjacent tissues from pa...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11666
更新日期:2020-08-01 00:00:00
abstract::Telomeres are located at the ends of chromosomes and protect them from degradation. Suppressing the activity of telomerase, a telomere-synthesizing enzyme, and maintaining short telomeres is a protective mechanism against cancer in humans. In most human somatic cells, the expression of telomerase reverse transcriptase...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2020.11659
更新日期:2020-08-01 00:00:00
abstract::Effects of miR-135a-5p and miR-141 on the biological function of colorectal cancer SW620 cells were investigated. Fifty-four specimens of cancer tissues and 54 specimens of corresponding adjacent tissues in colon cancer patients who were treated in The Central Hospital of Wuhan from March 2014 to March 2015 were colle...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11598
更新日期:2020-07-01 00:00:00
abstract::In patients with bladder cancer (BC), the association between ST3 β-galactoside α-2,3-sialyltransferase 5 (ST3GAL5) expression and clinical outcomes, particularly regarding muscle-invasive disease, high tumor grade and prognosis, remain unknown. In the present study, the expression of ST3GAL5 and its association with ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11597
更新日期:2020-07-01 00:00:00
abstract::The present study investigated the value of combinations of five specific tumor biomarkers for the diagnosis of colorectal cancer (CRC): Neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), cancer antigen (CA)19-9, CA125 and CA242. Associations between these markers and clinicopathological characteristics (i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11633
更新日期:2020-07-01 00:00:00
abstract::KRAS mutation is frequently identified in advanced colorectal carcinoma (CRC); however, its prognostic significance and the associated histological features have remained to be clarified. In the present study, the precise histological results and prognostic value of KRAS-mutated CRCs were investigated in patients from...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11606
更新日期:2020-07-01 00:00:00
abstract::Cancer metastasis, particularly multiple metastatic cancer, is a significant event that affects patient prognosis. However, single metastasis can be treated by partial resection, although the clinicopathological and molecular profile of single lung metastasis has not been thoroughly elucidated. The present study exami...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11627
更新日期:2020-07-01 00:00:00
abstract::Signal transducer and activator of transcription 6 (STAT6) is a member of the STAT family of proteins that serve key roles in the initiation of tumorigenesis and malignant transformation. STAT6 is highly expressed in several types of cancer, including breast, pancreatic, prostate and colorectal cancer. STAT6 transduce...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2020.11614
更新日期:2020-07-01 00:00:00